The supplemental videos to the paper "Spatial model of lymphocyte search in influenza-infected lung reveals constraints on chemokine directed migration" are embedded below and can be found on YouTube here: YouTube Playlist
The first of three overlaid videos of a representative seasonal H1N1 infection. This video spans the 10 day infection and shows the cells as they transition from healthy to infected to dead. T cells show half way through the simulation. Healthy cells are gray, virus-incubating cells are yellow, virus-secreting cells are orange, apoptotic cells are red, and T cells are green.
The second of three overlaid videos of a representative seasonal H1N1 infection. This video spans the 10 day infection and shows the virus concentration. Notice the volatility when T cells arrive halfway through the simulation. Virus concentration ranges from 1e-13 mols/mL (white) to 1e-27 mols/mL (black). Refer to Figure 5 for the detailed legend.
The third of three overlaid videos of a representative seasonal H1N1 infection. This video spans the 10 day infection and shows the chemokine concentration. Notice the volatility when T cells arrive halfway through the simulation. Chemokine concentration ranges 1e-6 ng/mL (black). Refer to Figure 5 for the detailed legend.
A closer look at the 2009 pandemic simulation. This video shows the infection from day 6 to day 7 with each frame spanning 1 simulated minute. Healthy cells are gray, virus-incubating cells are yellow, virus-secreting cells are orange, apoptotic cells are red, and T cells are green. Note the high proportion of virus-secreting cells (orange) early on. As time passes, secreting cells are gradually contained to the point where they become very sparse. T cell clumping often prevents the T cells from quick discovery of new secreting cells.