Deoxyribozyme-Based Ligase Logic Gates and Their Initial Circuits

Apr 26, 2005·
Milan N. Stojanovic
,
Stanka Semova
,
Dmitry Kolpashchikov
,
Joanne Macdonald
,
Clint Morgan
,
Darko Stefanovic
· 0 min read
Abstract
A complete set (YES, NOT, AND, and ANDNOT) of molecular scale logic gates based on ligase deoxyribozymes was constructed. The activity of these gates was visualized through the formation of cascades with downstream phosphodieseterase YES gates, which performed fluorogenic cleavage.
Type
Publication
Journal of the American Chemical Society, 127(19), 6914-6915