Medium Scale Integration of Molecular Logic Gates in an Automaton

Oct 7, 2006·
J. Macdonald
,
Y. Li
,
M. Sutovic
,
H. Lederman
,
K. Pendri
,
W. Lu
,
B. L. Andrews
,
D. Stefanovic
,
M. N. Stojanovic
· 0 min read
Abstract
The assembly of molecular automata that perform increasingly complex tasks, such as game playing, presents an unbiased test of molecular computation. We now report a second-generation deoxyribozyme-based automaton, MAYA-II, which plays a complete game of tic-tac-toe according to a perfect strategy. In silicon terminology, MAYA-II represents the first “medium-scale integrated molecular circuit”, integrating 128 deoxyribozyme-based logic gates, 32 input DNA molecules, and 8 two-channel fluorescent outputs across 8 wells.
Type
Publication
Nano Letters, 6(11), 2598-2603